Because of the inability to adequately monitor infection rates in the chronic disease, clinical trials for drugs against Chagas disease are exceedingly challenging, made further so by the low-resource regions in which the clinical trials must be performed.
As accounting for these additional levels of regulation in multiple biopsies would be exceedingly challenging, targeting multiple tumor clones might best be accomplished using immunotherapy approaches such as tumor-lysate stimulated adoptive cell transfer or immune regulatory check point blockade agents such as ipilimumab.
However reticent he is on that score, his ambition as a general was matched with an exceedingly challenging assignment on the ground in Iraq.
The new rules reward difficulty above all else: even a stumble on an exceedingly challenging feature can still yield more points than a textbook performance of a more straightforward one.
The man who defeated Eberharter in the 2001 worlds, the American Daron Rahlves, had another disappointing day today, skiing conservatively and with chattering skis through the exceedingly challenging midsection to finish eighth.
"Running a profitable first-class club is exceedingly challenging," said Sussex chairman Jim May.
It's okay to give yourself permission to be mildly irresponsible during this exceedingly challenging time.
She's a single mother, she's also a professional, by means of her vocation, she's a criminal lawyers, and she's put through exceedingly challenging situations.
This paper discusses CHPS progress in the Upper East Region (UER) of Ghana, where the pace of scale up has been much more rapid than in the other 9 regions of the country despite exceedingly challenging economic, ecological, and social circumstances.
Accordingly, they heterologously express OCA2 in mammalian cells, showing that the protein is directed to the endolysosomes, and in exceedingly challenging patch-recording experiments document a new current appearing in dissected lysosomes.
There are particular circumstances that are exceedingly challenging both for the individual concerned and their family.
