Merge analysis tests if the association between a trait and a SNP genotype exceeds the significance of an association using a multi-allele model.
It is explained by revascularization of the ischaemic or viable myocardial tissue, which exceeds the significance of decreased HRV and autonomic dysfunction [ 34].
DOI: http://dx.doi.org/10.7554/eLife.09178.008 To distinguish between intragenic and extragenic modifiers, we considered the list of 129 associated SNPs (in 27 haplotype blocks) with p-values less than 10−4 (Supplementary file 2), all of which exceed the significance of the validated lsy-22 and pkc- 3 modifiers.
A copy number alteration was defined as exceeding the significance threshold of 1 × 10−6 in a minimum of 5 consecutive probes and in more than 30% of the samples.
This result did not depend on the cell-growing substrate, though it was more prominent for collagen I. Probably the higher the TGFβ1 concentration, the greater the number of genes exceeding the significance threshold.
Most differences were small and statistically non-significant, but 12 (11.4%) exceeded the significance level of 0.05 (Table 1).
After multiple end point adjustment (α = 0.05; number of tests = 44; overall correlation among cognitive outcomes = 0.39), however, all reported p-values exceeded the significance level of p = 0.0051 (Tukey et al. 1985).
Considering that insignificant SNPs from univariate analyses are not likely to exceed the significance level of multivariate test and handling all SNPs simultaneously would increase computational burden, thus we only analyzed those suggestive SNPs from the univariate results in a multivariate model.
Although the first recently reported GWAS for viral load set point in African Americans failed to identify risk loci that exceeded the significance thresholds required of genome-wide searches, the associations with HCP5 and HLA-C were validated [ 13].
In Table 2, the p value of the Kolmogorov Smirnov test exceeds the significance level 0.05 for all of the experiments, signifying that these results are likely to follow the normal distribution.
