For these patients, a new therapeutic approach, for example, with biologicals with hardly any toxicity, may be a more attractive treatment option.
This observation will be further demonstrated by examples with added biological complexities in subsequent sections.
The advantages and limitations of various codon-based models are compared, and illustrated by examples with real biological complexities such as slow codons, premature termination and feedback regulation.
Fumigation with ethylenoxide, for example, interferes with biological analysis since it intercalates with DNA and RNA which cannot be recovered anymore (Michaelsen et al. 2013).
The genomics explosion in sequencing and bioinformatics has generated enormous amounts of data, but there are limited resources to integrate genetic changes in a pathogen, for example, with multiple biological, environmental, and population variables.
In this paper, we have discussed five different cases, with biological examples, that we might wish to model ontologically; for each, we have presented different models, describing the same underlying science.
Examples of alginate/mucin interaction with biological relevance have been shown previously (Taylor, Pearson, Draget, Dettmar, & Smidsrod, 2005).
For example, same-sex couples with biological or step children show evidence of economic disadvantage.
The in vivo antitumor activity of mAb C7/pc42 H2 and mAb HuA L1, the protection conferred by mAb C7/pc42 H2, H2 and mAb C7 L1 against invasive candidiasis, as well as ex vivo inhibitory activity of mAb pc42 L1 against HIV-1 are examples of hypervariable Ab sequences with biological activity.
The gene ontology analysis (Additional file 1: Table S1) which revealed enrichment of functional categories associated with uAUG and uAUG-less genes, provides examples for coordination of expression level with biological activity.
