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Using information gleaned from these examples, we designed the potential kinase inhibitor chemotypes I and II by expanding the 6-membered pyridone ring of BI-2536 to a 7-membered lactam ring.
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As a second example, we designed a 1 × 9 switch with similar features and a corresponding footprint of 80 × 30 μm2 (d=55 μm), see Figure 6f.
As an application example, we designed a heat flux inverter which was so simple that it could be hand-made.
As an example, we designed and analyzed the fused-silica multilevel ARGs by using the MM and the commonly used second-order effective medium theory (SEMT).
For example, we designed our online application to be interactive with tips and feedback along the way -- not a linear, traditional mortgage application that's been retrofitted for the web.
For example, we designed this huge, specialty bookcase for a client in the West Village.
For a third example, we designed a novel riboswitch module that consists of only 27 nucleotides and verified its function using the 2′-SCF3 labeling concept.
For example, we designed the 42-helix bundle and the 100-helix bundle using improved strand-breaking and self-assembly procedures.
As an example, we designed various modular logic devices using transcriptional modules from the hrp (hypersensitive response and pathogenicity) gene regulation system for Type III secretion in Pseudomonas syringae (Fig. 1).
For example, we designed and built a long poly-ZF protein able to bind to expanded stretches of CAG repeats, a mutation found in polyglutamine disorders, such as HD (Box 1).
For example, we designed a measure that computes the topological similarity of the extended network neighborhoods of two nodes, without the nodes necessarily being close in the network (Milenković and Pržulj, 2008).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com