For example, the tissue could be grown to size for a child or an adult, and it might possibly be grown in advance and stored for later use.
However, it can be observed that the uTE-derived mu-map lacks detail elsewhere in the body (for example, the tissue of the left lung is incorrectly segmented) and therefore requires further optimization for this purpose.
Only the confocal can image clearly through the depth of a sample, however it too has disadvantages, for example the tissue may shrink after dissection and can be subjected to shape distortion due to dissection and the mounting procedure.
In order to examine tissue under a light or transmission electron microscope, for example, the tissue is generally embedded in wax or plastic and then sliced into sections.
Firstly because in the clinical practice of taking rectal cancer biopsies, for example, the tissue is taken from the patients and transferred into RNA conserving fluid within less than 20 seconds.
Current approaches to network analysis represent static scenarios where spatial and temporal aspects are not taken into account: for example, the tissue and stage of tumor development are not considered.
For example, the tissue specific spots A (nervous system tissues), B (muscle tissues) and F (immune system tissues) contain about 30% - 40% genes which are not assigned to any of the gene sets tested and about 50% genes which are members of gene sets not listed at the top of the list (details are given in Additional file 1).
For example, the tissue distribution of PrPSc in vCJD differs strikingly from that in classical CJD and inherited prion disease [ 51– 55, 57, 57, 61, 124] with uniform and prominent involvement of lymphoreticular tissues, with the highest amounts (up to 10% of brain concentrations) in tonsil [ 52, 124].
The cell state into which mutations are introduced is of crucial importance; for example, the tissue and developmental origins of the cell (Li et al., 2005) and its position in the cellular hierarchy (e.g. somatic stem cell, committed progenitor, mature cell) (Bonnet and Dick, 1997) are among the many factors that affect the outcome of mutations.
For example, using the "tissue" example above, a subsequent curator can reify this protein as "[e]xpressed in muscle fibers and the brain" (Wiki For Professionals 2007).
