For example, medications that target specific mediators of the immune response have proved effective in the treatment of uveitis.
For example, compounds that target SMAC-binding sites on BIR domains activate the intrinsic E3 ligase activity of IAPs, causing their self-ubiquitinylation and subsequent proteasome-dependent degradation (Zhang et al, 2004).
For example, one that targets all potential child sex offenders, and not merely those people with a paedophilic interest.
More research is needed that is designed specifically to reduce disparities in healthcare quality, for example, research that targets specific diseases (e.g. cardiovascular disease, diabetes, HIV) and healthcare processes known to be a source of racial/ethnic disparities.
John Doull, professor emeritus at the University of Kansas Medical Center, gives the example of chemicals that target certain regions in the brain whose toxic effects are reflected elsewhere, perhaps in terms of gait or vision.
Cell line S462 appears therefore as a good model, for example for testing drugs that target proteins encoded by genes within the amplicon.
This review describes the design and expression of diabodies, triabodies and tetrabodies using examples of scFv molecules that target viruses (influenza neuraminidase) and cancer (Ep-CAM; epithelial cell adhesion molecule).
Some examples of TEL environments that target these skills include Web-based Slottae Environment (WISE) (Slotta, 2004), Web-based inquirer with modeling and visualization technology (WiMVT) (Sun & Looi, 2013), Model-It (Fretz et al., 2002), Co-Labs (van Joolingen et al., 2005), and Go-Labs (Govaerts et al., 2013).
Retailers committed to reducing waste sent to landfill to below 15% by 2013, for example, and signatories beat that target two years early, sending just 14% of waste to landfill last year.
To explore this concept of using signatures as the basis for a drug screening strategy, we have made use of several examples that represent potential drug targets and coupled these with data from the NCI-60 cancer cell line drug screening panel.
