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This fact is rather surprising given the number of impressive natural product examples that confer their activity by stabilizing specific PPIs.
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For example, traits that confer tolerance to low resource availability (e.g. high resource use efficiency, low tissue turn-over) may not be the same traits that determine the ability of a plant to pre-empt resource capture (e.g. early phenology, high growth rates).
For example, genes that confer resistance to antibacterial drugs have transferred from one species of bacteria to another, and other genes have also 'jumped' from bacteria to plants or animals.
These are striking examples of mutations that confer strong protective effects against cardiovascular disease and diabetes, respectively.
For example, the eight mutants that confer the strongest defects in Spt16−gene interactions (H3-L61I, Y, E, H, V, T, K, and W) are also the ones that show the most robust growth on SC-his GAL plates.
Our goal is to identify genomic variants, for example mutations or recombination events that confer a fitness advantage when the phenotype of interest such as antibiotic resistance, virulence, evolves under selective pressure.
The plasmids, transposons, and mobile chromosome cassettes that contribute to antibiotic resistance, including methicillin resistance, in Staphylococcus aureus are examples of well-studied extrinsic elements that confer antibiotic resistance [16].
In other examples, the elevated expression of transporters that confer MDR merely coincides with a trait that is responsible for collateral sensitivity.
Without knowledge of the kinetics of amyloid deposition in pathological aging, it will be difficult to determine whether there are actually factors that confer protection (for example, genetic variants, cognitive reserve) to toxic effects of Aβ accumulation.
Known HLA variants that confer risk to CD, for example, include DQA1*05/DQB1*02 (DQ2.5) and DQA1*03/DQB1*0302 (DQA1*03/DQB1*0302
For example, the HLA-DQA1 and -DQB1 genes have alleles that confer risk to both CD and T1D.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com