There are several other examples of markers tightly linked to resistance genes, but whose use present problems in material different from the original in which they were identified [ 48].
These examples of a tightly regulated expansion of Teff and Treg cells lend support to the hypothesis that in response to an antigenic stimulus, Tmem clones give rise to both Teff- and Treg-cell populations that subsequently expand 18, most probably in response to the presence of cytokines such as IL-2, in order to maintain immune homeostasis.
A striking example of a tightly controlled network function involves food sharing, a fundamental behavior in eusocial insects15,16,17,18,19.
An example of a tightly linked dual-domain reader is the PHD-BRD of TRIM24, in which both domains interact through a large interface that orients both peptide binding cavities to the same side of the protein (Tsai et al., 2010).
For example, in a region of tightly packed axons arranged along a common average orientation, water motion is less hindered along the axons than across them.
It may be, for example, that introducing a system of tightly linked process measures into the diabetes domain, similar to the system used by the Veterans Administration, 20 could improve care further, although this would require some modification to the information technology infrastructure underpinning the quality and outcomes framework.
For example, if an oncocytoma predominantly consists of tightly packed tumour nests, the tumour would show avid arterial enhancement and subsequent washout in the nephrographic phase (Fig. 1).
But the researchers maintain that they are aware of numerous examples of bands being fitted too tightly, and say there is a need for stricter rules.
Hespos and Spelke showed infants repeated examples of a cylinder being either tightly or loosely fitted into a hollow container until the babies became bored.
