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However, therapies directed at HRDs are not the only examples of therapy that could be individualized by using genomic scar-based biomarkers.
Participants were individually encouraged to make self-adjustments to their treatment using real-time CGM values, hyper- and hypoglycaemic alerts and trends, or to incorporate self-monitoring of blood glucose (SMBG) results into treatment adjustments, with written examples of therapy changes provided in the optional patient diary.
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There are many human examples of therapies that target diseases, without a complete understanding of the root causes of those diseases.
As illustration, we present examples of therapy-induced drug resistance and discuss implications for new therapies.
Both the drug methotrexate (MTX) and the biologic agent etanercept are examples of therapies widely employed to treat rheumatoid arthritis.
In fact, it is clear that, in spite of the initial enthusiasm, anti-angiogenic drugs, one of the most prominent examples of therapies based on the disruption of growth factors, have been disappointing.
Examples of new therapies are endocrine therapy with third-generation aromatase inhibitors, cytotoxic therapy with taxanes, and targeted therapies with monoclonal antibodies such as trastuzumab and the novel bisphosphonates.
While there is evidence to support the role of occupational therapy in health promotion and prevention, there have been few practice examples of occupational therapy within primary care settings [ 3, 4].
Some most recent examples of multimodality therapy and theranostics are shown by Nellore et al. [86].
Relevant examples of gene therapy studies for neurodevelopmental disorders, as well as outstanding challenges, are discussed.
The therapeutic silencing of this protein has been one of the most successful examples of targeted therapy.
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