No standard examples of these modalities were provided by the interviewer, and no further details regarding frequency, duration, or purpose of use were elicited.
Examples of response modalities included in the 'facial expression' item are 0 = smiling; 1 = sad, frightened, frowning; 3 = facial grimacing [ 49, 50].
They appear in that order, for example, in his division of the modalities into possibility, actuality, and necessity; in his division of signs into icons, indexes, and symbols; in the division of symbols into terms, propositions, and arguments; and in his division of arguments into abductions, inductions, and deductions.
Examples of treatment modalities (less vs more conservative modalities) include bilateral versus unilateral ECT, three times versus twice weekly treatment, ultrabrief versus brief pulse, sine versus pulse, ECT versus pharmacological treatment, ECT versus no treatment and ECT versus sham.
On the other hand, using two extracts of discourse between a registered nurse and patient, (Candlin 2000, 237) argues that the projecting nexuses of cognition in her texts are examples of subjective modality and demonstrate "a low affinity to the proposition, and evidence of doubt".
Substrate reduction therapies and molecular chaperone therapies are examples of two therapeutic modalities with active ongoing clinical trials in some IEM (http://www.clinicaltrial.gov).
