Your English writing platform
Discover LudwigExact(2)
This is one of the most challenging examples of substrate and cofactor specificity that has not yet been fully elucidated.
Numerous examples of substrate channeling have been reported, including DNA replication, RNA synthesis, purine and pyrimidine biosynthesis, protein biosynthesis, amino-acid metabolism, lipid metabolism, glycolysis, and the tricarboxylic acid cycle, etc. (10– 10).
Similar(58)
Finally, in the examples of substrates not having phosphate groups present, GlcNAc, Glc and U, the binding of Mg+2 and Mn+2 to the substrates was so weak as to preclude accurate binding affinity determinations, which indicates the importance that the charged phosphates play in binding divalent metals.
To develop an in silico tool for identifying substrates of the yeast Ste20p kinase, our first step was to generate a learning set of positive and negative examples of substrates.
Despite numerous structural reports, there have not been many examples of substrate-bound or product-bound structures (4– 9), making studies of mechanism and inhibition more difficult.
The results provide an example of substrate effect in self-assemblies of functional molecules, which is significant for the design of molecular based devices.
In this view, Put2p would be an example of substrate recognition by conformational selection.
The preparation of the two enantiomers of 2-methyl-3-aryl-propanols by fermentation of two regioisomers represents an interesting example of substrate-controlled enantioselective reaction.
A well-known example of substrate-dominated self-assembly is the epitaxial stripe nanopatterns formed by alkanes and alkane derivatives on highly oriented pyrolytic graphite (HOPG) [4 10].
Some of the examples of overlapping substrate specificity include K-Ras and Rho B proteins.
This indicates that the observed effects are not artefacts of ectopic expression of PTEN, for example, loss of substrate specificity due to overexpression.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com