This would help to place into context the mentioned examples of signature genes that match what is known in the literature.
Also, are there any examples of signature genes whose expression profiles do not match with what is assumed in the literature, or known 'markers' from the literature that fail to show up as signature genes?
Examples of these signatures are the "Wound signature" that includes genes expressed in fibroblasts after serum addition with a pattern reminiscent of the wound healing process [5], [6], the "Hypoxia signatures" that contains genes involved in the transcriptional response to hypoxia [7]-[9], and the "Proliferation signatures" that include genes expressed in actively proliferating cells [10], [11].
Perhaps the best examples of such signatures are the plasmablast and granulocyte signatures seen in SLE patients; both reflect plasmablasts or immature granulocytes present in the PBMC.
That is as strong an example of signature significance as one could hope to find.Applying this principle to Mr Rodríguez's case is tricky.
Taniguchi's aim, he says, has been to create an "environment for art" rather than an example of signature architecture.
Genuine examples of many signatures abound; Hemingway, for example, signed lots of letters, bar coasters and bullfight programs.
Examples of gene signatures which were obtained by studying the relationship between gene expression profiles and clinical outcome, are the 70-gene (van't Veer et al., 2002) and 76-gene (Wang et al., 2005) signatures.
Examples of molecular signatures are the list of genes which are specifically expressed to higher levels in a given cell type, cell state or disease as compared to many other ones.
In some cases, the cause and effect is direct — for example, in the case of signature Tiger Woods golf shirts sold by Nike.
