Our series did not have any examples of mediastinal recurrence.
Studies have shown that tumour growth rate is a valuable parameter for, for example, prediction of recurrence after surgery (Cucchetti et al, 2005) and survival of patients (Blankenberg et al, 1995), and the change in tumour growth rate can serve as a surrogate end point for determination of therapy response (Haney et al, 2001).
If, for example, 75% of recurrences are found in the first five years (doubling time < 3 months), 20% of recurrences in years 5 15 (doubling time 3 9 months), and 5% of recurrences in years 15 25 (doubling time 9 15 months), the metastatic efficiency for 0 3 month doubling time would be approximately 6-fold higher than for 3 9 months, and approximately 24-fold higher than for 9 15 months.
An example of local recurrence detection and localization is provided in Fig. 1.
For example, the risk of recurrence for a patient with negative axillary lymph nodes and a tumor measuring 1 2 cm is approximately 20 30%.
For example, individualized AO estimates of recurrence risk are sensitive to variability in comorbidity assessment [ 3], and its (Adjuvant! Online) estimates of recurrence are not truly individualized, because they are based on data incorporated into 'binned' categories (tumor size, nodal status, and so on) [ 4].
For example, oncotypeDx estimates the risk of recurrence using a proprietary algorithm that is dependent on the expression of proliferation-associated genes that are controlled by RB/E2F [ 65, 66].
For example for the reports of incidence of recurrence studies of special populations such as those of families at increased risk of cancer were excluded.
However, there is clearly a subgroup of long-term survivors (for example, those with actual and fear of recurrence) who have high levels of distress that merit help.
Risk profiles of the low-, andrage-, and high-risk example patients showed non-uniform distribution of recurrence risks (2.9, 7.6, and 9.2%, respectively, over a 5-year period).
