It is intriguing, then, that the literature on genome architecture, experimental evolution, and repair also contains examples of origins of replication associated with breakpoints.
Specific examples of the origin and functions of macrophages during healing of various tissues are illustrated below, with particular emphasis on skeletal muscle.
For example, upstream of origin ARS422, ∼90% of forks were traveling leftward, whereas downstream of the same origin, ∼20% were traveling leftward.
Other examples of BDNF origins other than from CNS are white cells [ 12– 14] and platelets; the latter contain significant quantities of this protein and might provide an important source of this circulating neurotrophin [ 5].
They can also help guide design of follow-up experiments in those resources: for example, strong parent-of-origin epistasis suggests an advantage of reciprocally intercrossing CC lines (i.e., to form a recombinant inbred intercross, or CC-RIX), whereas strong additivity and epistasis but no parent-of-origin effects suggests more immediate value in designs using the CC and DO directly.
For example, recruitment of origins a quarter of the way 'up' a loop would initially cause only a maximum of 12.5% drop in loop size (Fig. 2C), and the closer the origin is to an existing S/MAR the less the effect would be.
Although such a system is certainly far from foolproof, wikis stand as an example of the origin of an Internet counterculture that has a basic assumption of the goodness of people.
The evolution of vasopressin and oxytocin family hormones is a classical example of the origin of a novel gene by the duplication of a gene.
Beyond the Fungi, the oomycetes, chromistan fungus-like protists, provide an example of convergent origin of hyphae.
Thus, this scenario is more parsimonious and likely represents the third example of independent origin of the chimeric mtrA-F gene through concerted evolution.
