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Several examples of linkage drag in tomato and other crops have been quantified using molecular markers [ 17- 21].
Such studies seem to work well, the first examples of linkage studies show significant findings in samples of relatively limited size (e.g. [ 42, 150]) and so do (candidate gene based) association findings (e.g. references to Durston et al. [ 45]).
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Mexico and Thailand provide the clearest examples of linkages between embedded evidence-generating organizations and decision-makers to inform health sector governance.
These projects cover a wide range of functionality, are heavily used by the scientific community and as they are open, there are a number of examples of linkages between these projects.
A clear example of linkage involves the wild silver foxes (bred by Soviet biologist Dmitri Belyaev for tameness) which ended up looking much like domesticated dogs with curled tails and floppy ears (Trut 1999).
An important example of linkage data being utilized to guide candidate gene association analysis is CNTNAP2, found associated in two studies (Alarcón et al, 2008; Arking et al, 2008), with further evidence from a subsequent genome-wide association study (GWAS; Anney et al, 2010).
51 Innovative examples of data linkage include combining mobile phone usage with police records to show the impact of phone calls on collisions while driving, 52 and linking social care with hospital data to predict future usage of social care.
Examples of interspecific linkage drag are found in tomato (Robert et al. 2001; Tanksley et al. 1998) and its related crop species potato (Danan et al. 2011; Visker et al. 2003).
In one of the clearest examples of the linkage between health and housing, public health officials warned over 100 years ago (Gibson 1904; Turner 1897) against permitting the use of lead paint in housing, a legacy only recently addressed in the United States (Jacobs 1995; Markowitz and Rosner 2002) and in France (Fassin and Naude 2004).
The best known examples of close linkage between homeobox genes are the four Hox clusters on human chromosomes 2, 7, 12 and 17, comprising 9, 11, 9 and 10 genes respectively; each of these is shown as just a single line on each ideogram for simplicity.
For example, evidence of linkage reported between KRTAP6-8 and wool fiber diameter (quantitative trait) in sheep [ 94] may be related with similar characteristics in alpaca (fiber), which has one of the largest number of KRTAP6 genes (n = 9) in mammals.
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