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Malnutrition [2], hypercholesterolemia [3], and diabetes [4] are examples of host nutritional conditions associated with increased susceptibility to TB.
The plant initiation factors eIF4E and eIFiso4E and their respective partners eIF4G and eIFiso4G are examples of host factors that are required for potyviruses to infect plants.
Another clade was represented by all specimens from M. robustus robustus and M. rufus, together with two examples of host switching by the nematode into M. fuliginosus.
Host-associated biotypes are well documented in plant-feeding insects, and many examples of host races have been described in phytophagous insects in the last ten years.
We review the rationale and resources for comparative genomic analysis and describe three examples of host resistance genes successfully identified by this approach.
Examples of host cellular components that are mimicked by viral proteins include mimicry of receptors and antigens of the immune system.
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There are more recent examples of host-city blowback, as well.
Need more examples of host-switching?
Scientific literature contains several examples of host-pathogen interaction genes with evidences of balancing selection.
A second example of host heterogeneity is the observation that the binding of interferon to its cellular receptor triggers a far more attenuated transcriptional response in African-Americans compared to Caucasians [95].
In addition to the obvious example of host proteins, this scenario represents constant stimulation by commensal bacteria in the gut, or low level, chronic exposure to an environmental agent like pollen or dust mites.
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