Another example of heterogeneity can be seen in the pattern of inhibition resulting from staurosporine (1 µM) inhibition of protein kinase activity.
An interesting physiologically relevant example of heterogeneity is reported for the insulin producing pancreatic beta cells.
Present data provide not only an example of heterogeneity in T-ISC of TNBC, but also in molecular pathways and susceptibility to therapeutic targeting.
Mid -p exact confidence intervals were derived, and all hypothesis tests (for example, of heterogeneity of OR by heritability subgroup and age) were based on fitting appropriate generalisations of the above logistic model, with interaction terms to test for the desired effect (for example, departure from homogeneity) (Cox and Hinkley, 1974), and reported in Table 5.
The application of novel compounds might be feasible, for example in the case of heterogeneity in the target chemokine or chemokine receptor, for example due to post-translational modifications that modify the affinity of the target for an antibody or small molecule antagonist.
Several examples of ordered heterogeneity were given at the time to illustrate the principle, but many more have become apparent since then to confirm its generality.
(The first few probabilists' - as opposed to physicists' - Hermite polynomials are H 0 ( x ) = 1, H 1 ( x ) = x, H 2 ( x ) = x 2 − 1, … .) Thus, we approximate the integral in Equation 17 by the double sum: ∫ − ∞ ∞ ∫ − 1 1 s ( V ( μ, λ, t ) ) p q d μ d λ ≈ ∑ j = 1 M ∑ i = 1 10 v j w i s ( V ( μ i, λ j, t ) ). (26) Fig. 11 Examples of the heterogeneity grid values of μ i and λ j for M = 15.
I suggested that these two families represented examples of the heterogeneity of insulin secretion in MODY.
Figures 1 and 2 provide examples of the heterogeneity of the time series.
Examples of such heterogeneity are shown in Figure S3, both for a series of genes linked in a PAV region and genes exhibiting UpCNV.
