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Clinical examples of fibrosis include renal interstitial fibrosis [ 43], scleroderma [ 44], sarcoidosis [ 45], idiopathic pulmonary fibrosis [ 46], retroperitoneal fibrosis [ 47] and DD [ 48].
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Specific examples of cutaneous fibrosis include hypertrophic scars (HS) among others [ 18].
Renal fibrosis is a paradigmatic example of organ fibrosis towards degenerative organ disease and final stage kidney damage leading to the destruction of the tissue and death from renal failure.
Cutting, G. R. Modifier genes in Mendelian disorders: the example of cystic fibrosis.
Take the example of cystic fibrosis: Some forms of the disease result when a genetic "stop sign" prevents the body's cells from making a complete version of the cystic fibrosis protein.
The purpose of this review is to provide insight into the role of modifier genes as an important source of phenotypic variability in so-called monogenic disorders, using the example of cystic fibrosis (CF).
While normal myocardium from humans and from chimpanzees are histologically quite similar (Fig. 1 uppermost panels), no human counterpart was observed of the mild, moderate or extensive IMF seen in chimpanzees (see Fig. 1 for an example of extensive fibrosis).
The example of cystic fibrosis, in which only 200 titles over a 3-year period have to be screened after the same time period of 3 years, shows that with more rare diseases application of the WDP-R filter is efficient for researchers and practitioners alike.
This review focuses on the role of modifier genes using the example of cystic fibrosis, the most common lethal autosomal recessive disorder in the white population, and discusses the advantages and limitations of candidate gene approaches versus genome-wide association studies.
The ultimate individual outcome might depend, for example, on the stage of fibrosis progression, the size of the lesion and comorbid conditions such as diabetes and arteriosclerosis.
Hepatobiliary scintigraphy with technetium-99m (99mTc -mebrofenin is a dynamic quantitative liver function test; for example able to assess severity of fibrosis in hepatitis C-positive patients [6].
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