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This paper presents examples of developmental remnants, which often involve circulatory and reproductive alterations, and discusses numerous other retained or reappearing historical holdovers in ways that reveal the unfolding dynamic interaction between genotype and phenotype.
However, most recognised examples of developmental compensation relate to dramatic genetic or environmental insults [46] and it is unclear whether the generally smaller phenotypic differences induced by common functional polymorphisms, as used in our study, will be sufficient to induce compensatory responses.
It also provides examples of developmental immunotoxicants where age-based risk appears to differ.
All of these processes are examples of developmental programming of DNA methylation, which are generally considered to be relatively stable.
Many examples of developmental regulation through bivalency have been published at non-imprinted genes (reviewed in [ 62]).
The evolution and development of the vertebrate limb, for example, provides several examples of developmental genetic heterochrony.
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As an example of developmental skeletogenesis, the developing limb bud serves as an excellent model system in which to study how osteochondral structures form from undifferentiated precursor cells.
We hypothesized that due to the unusual demands of metamorphosis, Xenopus would provide a fascinating example of developmental plasticity during a major developmental transition.
Gonad differentiation is an excellent example of developmental plasticity (Siegfried 2010).
This programmed wave of autophagy in the larval fat body of holometabolous insects (those undergoing complete metamorphosis) is now known as an example of developmental autophagy.
We view this phenomenon as a classic example of developmental plasticity operating to ensure survival to reproduce but resulting in antagonistic pleiotropic disadvantages in later life.
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