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However, there exist other examples of alterations in multiple components of the same signalling pathway that may lead to a multi-level modulation of its activity.
A subset of these 70 genes is shown in Table 3 where key examples of alterations in metabolic processes are shown.
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Colorectal cancers (CRCs) provide a striking example of alterations in DNA methylation that occur during tumor development.
A prominent example of alterations in B-cell longevity leading to lupus is provided by B-cell activating factor (BAFF) transgenic mice.
Hence, this analysis confirms the initial interpretation of the source of phenotypes associated with rpn12a-1, andocumentsts an interesting example of alteration through mutation of a balance between 3' splicing and polyadenylation of a precursor RNA.
Activities including ion exchanges and modifications in swelling pressure and rock water content are examples of chemical alterations; they occur when there is a disparity between the water activity in the rock and the water activity in mud (Chen et al. 2003a).
Examples of severe alterations observed during clinical evaluations are shown in Fig. 1.
Indeed, examples of epigenetic alterations that result in a phenotypic trait in the presence of a specific transcriptional program have been described (Vanharanta et al., 2013).
Although RNA editing may change genetic information that, in turn, may generate genetic instability in neoplasms, only few examples of such alterations were described in neoplasm.
Examples of quantitative alterations have been reported for several antimetabolites, which influence various steps the metabolism of nucleic acids, through inhibition of key enzymes, such as thymidylate synthase and ribonucleotide reductase.
For these two examples of environmental alterations (food limitation: D.24 vs. D.starv) and extreme temperature shift (B.24 vs. B.6), our data show that the transcriptomes are indeed much more similar compared with the selected individuals of spontaneous transformants, namely the selected 51B expressing cells from the D.24 cultures that were cultivated under identical conditions.
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