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Within these examples, genes that are upregulated often have the GC16 or GC19 activated epigenetic signature, while downregulated genes have the opposite GC15 repressed differential profile.
For examples, genes that are expressed highly in proliferating keratinocytes (cluster 4) are associated with skin blistering and hyperkeratosis (e.g., KRT5).
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Dr Perls speculates that some kinds of disease-resistant genes may be involved for example, genes that are better at repairing DNA, or genes for metabolic processes that produce rather fewer damaging, oxygen-rich free radicals.That might explain why what looks to be a big genetic advantage is actually so rare in the population.
Other results confirm that dopamine function is key to this – so, for example, genes that control dopamine function predict personality differences in how much people enjoy the unfamiliar and actively seek out novelty.
For example, genes that are tissue specific have been identified and used to describe the biological processes associated with human organs [9].
It is a potential tool to study the functional role of unknown genes in bulk, for example, genes that have been identified in a high-throughput and comprehensive manner.
For example genes that make up the mitochondrial electron transport chain appear to decrease with age in different tissues, and this is supported in that decreases are also evident in mice and flies [6].
For example, genes that encode for CXC-chemokines such as CXCL1 (Gro-α), CXCL5 (Ena-78) and CXCL9 (MIG) were significantly induced at D12 and were induced to higher levels on D15 and D21 post infection (Table 7).
For example, genes that participate in the desmoplastic response can be distinguished because their expression is a shared feature in a variety of different pancreatic diseases in which this response is seen.
For example, genes that were positively selected in a uropathogenic E. coli (UPEC) genome were identified using phylogenetic analysis by maximum likelihood (PAML) of several E. coli genomes and verified in a sample of UPEC clinical isolates [10].
Users can search, for example, genes that can affect the abundance of the queried metabolites and vice versa.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com