While this stage allows one to downsize the conformer models to more manageable size, it may result in a loss of the ability to reproduce experimentally determined "bioactive" conformations, for example, found for PDB ligands.
A noticeable modification of the XRD pattern is, for example, found for brushite, for which the (020) experimental line becomes noticeably more intense than expected for randomly oriented crystals.
Less examples are found for triple - modality cancer treatment strategies.
His Iceland story, for example, found space for a digression on elves.
One study, for example, found that for every doubling in a fund's size, investors could expect a decrease of 21 basis points, or hundredths of a percentage point, in annualized performance.
A recent comparative study of male mating success in primates, for example, found evidence for the limited control model of reproductive skew (Kutsukake and Nunn 2006).
A similar pattern can for example be found for hsa-miR-504 and FGF13 [ 49, 50].
The Rockefeller Foundation, for example, found a cure for yellow fever and drove the "green revolution" in agriculture.
Groenewoud [ 25] for example, found empirical evidence for the existence of two types of consumers: those who focus on outcomes, and those who focus on trust.
Brungart (2001), for example, found that performance for the CRM task at negative SNRs differs approximately 20 percentage points between these talker combinations.
