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Recent literature gives plenty examples for the role of epigenetic changes in cancer [ 56, 63– 65], as well as their role in adaptive response to stress [ 24, 43, 44, 59, 66].
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Perhaps the best-established example for the role of LPA in cancer pathobiology is ovarian cancer.
Another example for the role of plate tectonics as driving force for speciation are amphibious tetrapods, such as salamanders.
A particularly prominent example for the role of the hypothalamus in homeostatic regulation has come over the years in the human and animal thermoregulation literature.
Daphnia, a group of model organisms in ecology, evolution and biomedical research [ 25, 26], provide a classical example for the role of modality.
As CXCL12 is abundantly expressed by stromal cells (Matsuo et al, 2009), this could be an exemplary example for the role of tumour microenvironment interaction in modulating the therapeutic response.
Moreover, apoptotic events in neutrophils were shown to be accompanied by H3T45 phosphorylation catalyzed by protein-kinase-C delta (PKCδ), constituting an interesting example for the role of histone H3 phosphorylation in programmed cell death [65].
Carnivores have sharply contrasting genome organizations, and are among the best examples for studying the role of chromosomal rearrangements in speciation.
In the last century or so, it hasn't been uncommon for men to take on, for example, the role of Lady Bracknell in Oscar Wilde's Importance of Being Earnest.
For example, the role of adjuvant therapy for gastric cancer has been controversial given the lack of high level, worldwide evidence.
A specific example for the regulatory role of Fas is exemplified by the response to LPS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com