This is approximately true for the studied examples since replication was attempted for one SNP in each genomic region, with two exceptions (5p13 and 5q33 in CD) in which the replicated SNPs were in weak linkage disequilibrium (LD).
Proposed solutions may also give rise to other challenges; for example, while replication is a hallmark for reinforcing trust in scientific results, there is uncertainty about which studies deserve to be replicated and what would be the most efficient replication strategies.
Our observations indicate that alternative splicing of HBP/SLBP mRNA may contribute to the regulation of histone gene expression; for example, during replication stress conditions by allowing for the synthesis of HBP/SLBP proteins with tailored functional properties.
For example, if replication were simply the passing on of structure largely intact without any subsequent translation, we would not be tempted to employ terms such as "information" in connection with it.
In L. lactis the longest genes represent major functions involved for example in replication, energy metabolism or transport (enrichment results not shown).
There are several factors to consider when interpreting GWAS for example, in replication of such studies, the consistency of the results vary [ 68].
Finally, if a RF collapses into a single-ended DSB, for example by replication run-off at a preexisting nick in the template, HR can mediate the reestablishment of a RF.
However, this variability does not generally affect calculation of ACE values; for example, while replication of Firmicutes involves distinct forms DNA polymerase III on each strand, leading to strong strand bias [ 51], the correlation between ACE values and dS does not improve when separate f n tables are created from leading and lagging strand genes (data not shown).
The risk allele was observed at much higher frequency in Iceland (3% in cases, 1% in controls) compared to other populations that served for replication (for example, 0.4% and 0.1% in Spanish cases and controls, respectively).
For example, replication fault tolerance schemes are storage and compute power intensive whereas process migration schemes are time intensive.
For example, replication initiation in bacteria is conducted by the replication initiation factor (DnaA) that recognizes replication origin (ori) and triggers the assembly of the replisome.
