For example, mechanistic biomarkers can be used to pre-clinically measure a drug's pharmacological activity in terms of its distribution and interaction with a defined protein target.
For example, mechanistic studies of all- trans retinoic acid (ATRA) and rapamycin, two well-studied Treg cell enhancers, pointed to roles for RAR-α and mTOR signaling in Treg cell differentiation respectively (Coombes et al., 2007; Mucida et al., 2007; Sun et al., 2007; Haxhinasto et al., 2008; Hill et al., 2008; Sauer et al., 2008; Hall et al., 2011).
For example, strong mechanistic data support tributyltin as a developmental obesogen, especially for its action through nuclear receptor signaling.
This contribution presents illustrative examples of this approach and discusses its consequences for mechanistic and kinetic interpretation of kinetic experiments and their design.
Fodor (1968), for example, contrasted mechanistic explanations (dealing with parts and their law-like interactions) with functional explanations in psychology.
For example, this mechanistic network of transcription regulators indicates whether the TF (orange color) and target gene (red gene symbol) are both activated or if the activity of the TF is inhibited (blue color), which would be associated with increased expression in the LL (green gene symbol).
Developing novel antiviral strategies requires efficient cell culture systems suitable for mechanistic studies and drug screens.
The work paves the way for mechanistic studies of how the environment affects microbial community assembly.
For example, the author states that while evolutionary biology attempts to answer the "why" question, developmental biology answers "how" and searches for mechanistic details couched at the gene level.
Cultured myocytes were used for mechanistic analyses.
