Having successfully validated requirements for IRF4 and MDM2, we individually inactivated RELA, NFKB1, and IKBKG, as examples for genes that unexpectedly did not score as essential in most screens.
Examples for genes with expression polymorphisms included the FAD3A gene (Glyma14g37350) (Additional file 2: Table S2).
For example, for gene therapy approaches, such as plasmid DNA, delivery to the heart is very inefficient whereas there are significant time delays associated with cardiac gene delivery using viral-based vectors.
For example, for gene B, this dimension of selection amounts to differentiating breast and ovarian cancers from lung cancer.
For example, for gene set c, the permutation P-value is, where T1 b and T2 b denote samples derived from the b-th permuted dataset.
The gene gumB, encoding an outer membrane xanthan exporter, is presented here as an example for genes that possessed a strong antisense TSS.
For example, for genes with low expression levels in the 11 tissues, our probe selection produced less reliable results.
For example, for genes KDR and MAPK1, their correlation coefficient is 0.63 in p53 normal group, but 0.01 in the p53 mutation group.
For example, for genes APC and NFKB1, their correlation is -0.60 in the dead group, but 0.03 in the survival group.
