The ability to identify mRNA targets directly, without relying on a change in their levels in response to perturbation of a specific miRNA, makes it possible to systematically investigate other possible miRNA-directed effects on their expression, including, for example, effects on subcellular localization or translation.
Many explanations are possible for the smaller variations in activity seen among the other mutants, including, for example, effects on the kinetics of prepore-to-pore conversion resulting from altered side chain interactions with domains 2 and 4 surrounding the 2β2 2β3 loop in the prepore [6].
For example, effects on LVEF associated with pegvisomant treatment could simply be related to regression towards the mean.
For example, effects on oxidative stress of N-acetylcysteine through the 1-C cycle, but also psychotherapy (21, 131– 135), may be interesting topics of future investigation.
Fish are highly sensitive to this insecticide, with for example effects on bluegill behavior at measured concentrations as low as 0.025 μg/L-1[ 28].
For example, effects on spermatogenesis in fish may not affect the population level in the laboratory, but this outcome may not hold true in the wild where males have to compete for females, and the conditions are generally less optimal.
For example, effects on PPAR metabolism, lipid metabolism, carbohydrate metabolism and amino acid metabolism likely represent interferences with systemic energy budgets as we have observed in other nitrotoluenes [ 11, 13, 15].
Even if patients' perceptions do not always correspond to objective negative or wrongful behaviour, these perceptions need to be taken seriously, because they seem to have consequences, for example effects on patients' self-estimated ability to return to work.
Although most cohort studies did not find significant effects of prenatal PCB exposure on the global mental development of infants, effects on global IQ tests were consistently observed during childhood in most studies (for example, effects on IQ were found in the Oswego, Netherlands, Michigan, and German studies).
For example, effects of practice on visual acuity were studied by requiring observers to detect simple orientation (left or right) in a row of leaning letters; e.g.,.
