In addition, our results indicate that different decision tree methods and workflows can be used for Vss prediction and we have shown an example of a model developed using Kt:p for adipose tissue.
To verify the effectiveness of the proposed fuzzy modeling method, two examples are developed using core and electrical log data from three oil wells in Ceuta Field, Lake Maracaibo Basin.
Two cancer drugs, for example, were developed using a rose periwinkle plant found in Madagascar, but the country received no benefit.Stopping "biopiracy" will be tricky, but multinational companies hate bad publicity, so many are striking fairer deals.
Another more recent example was developed using gold(I) complexes bearing 1,2,4-triazole-based N-heterocyclic carbene ligands for the formation of the corresponding ketimines from terminal alkynes and aniline derivatives.
For example, a PBPK model was developed using the results from a clinical pharmacokinetic study under single and multiple-dose conditions to predict the DDI for crizotinib with ketoconazole or rifampin [7].
A list of examples of drugs developed using SLN technology and their biopharmaceutical applications are summarized Table 6.
Examples of drugs developed using such strategy include Pfizer's Selzentry (Maraviroc) used for treatment of HIV Infection, SARcode's Lifitegrast ophthalmic solution and Roche's RG7112 (a potent and selective member of the Nutlin family of inhibitors of p53-MDM2 binding used in treatment of solid tumors) (10).
The Nottingham Prognostic Index (NPI), for example, which was developed using Cox proportional hazards modelling, has been widely used for this purpose (Blamey et al, 1979; Haybittle et al, 1982; Todd et al, 1987; Galea et al, 1992).
On the basis of a general mathematical model, a model of heat energy consumption was developed using an example the production of French fries.
Cisgenic GM potato that is resistant to 'late blight' is one example of a product developed using emerging plant breeding technologies, and serves as a good illustration of the complex socio-ecological, legal and political dimensions in which these agricultural biotechnologies are entangled.
