For example, cells with a gain of chromosome 20q11.1-11.2 had a significantly reduced propensity to differentiate down the hematopoietic lineage and in the neural differentiation experiments the variant cells displayed more immature phenotypes along the differentiation trajectory than their wild-type controls (Werbowetski-Ogilvie et al., 2009).
For example, cells with single and clustered cell attachment probabilities of 0.75 and 0.5, respectively, developed notably larger ALCs than did those with corresponding cell attachment probabilities of 0.5 and 0.75 (Fig. 10, inset).
For example, cells with overexpressed constitutively active Rac had elevated levels of PIP3 production, and treatment with Latrunculin A (LatA), an inhibitor for actin polymerization, led to an inhibition of the Rac-induced PIP3 production.
For example, cells with expanded mutations may die preferentially.
For example, cells with a strategy of damage repair can compete against cells with a strategy of damage segregation.
For example, cells with improved thermotolerance are easily isolated by mass growth on high temperatures (Steinmetz et al., 2002).
For example, cells with 30% of their surface area in contact with the Fn substrate would possess an α5β1 integrin value equal to 0.3.
DOI: http://dx.doi.org/10.7554/eLife.08902.004 10.7554/eLiFigure02 figuregure 2—figure supplement 1. Illustration of computing spatial modulation indices (SMIs) for two example cells with different firing rates.
For example, cells with a well-developed endo-lysosomal system and without secretory granules exhibit an extensive tubular TGN, while the tubular component of the TGN is reduced in cells that are specialized in regulated secretion (Clermont et al. 1995).
We next repeated the same type of simulations for the GLM. Figure 8D F shows the results of these simulations for the same three cells in Figures 8A C, and 5. Figure 8D shows an additional example cell with broader spectral tuning and stronger inhibition.
