For example, alterations have been shown in Alzheimer's disease, Morbus Parkinson, major depressive disorder and attention deficit hyperactivity disorder [1 9].
For example, alterations in intracellular calcium levels can affect smooth muscle contraction downstream [54].
For example, alterations in RSPO4 activity have been reported to cause anonychia in humans [22], whereas disruption of Rspo2 or Rspo3 in mice affects development of several different systems (skeletal, respiratory or placenta defects) [23].
For example, alterations in A-type lamins in humans correlates with changes in heterochromatin organization [68], whereas, Drosophila nuclei lacking Lamin C showed no obvious changes in heterochromatin (Fig. 4 and 5).
For example, alterations in the ECM simultaneously induce changes in viscoelasticity of the cartilage.
For example, alterations of auditory feedback during speaking can affect motor control of articulatory movements (Houde & Jordan, 1998).
For example, alterations to fibroblasts adjacent to the transformed epithelium involve proliferation, growth factor expression and even local estrogen production.
For example, alterations in contractile performance under ethanol exposure may simply be due to enhanced interstitial fibrosis but not reduced function of individual myocytes.
Mechanisms underlying this resistance to 'classical' cytotoxic chemotherapeutics include many features, for example, alterations in the drug target, activation of prosurvival pathways and ineffective induction of cell death.
MMPs play an important role in the homeostasis of the mesangial matrix, for example alterations on MMP function were shown to be linked to light chain diseases [ 75].
