For example, crossing APP mutant mice with transgenic mice carrying the P301L tau mutation, which is found in frontotemporal dementia, results in 100%% lethality by 4 months of age [ 43].
For example, the transgenic lines with the highest RFP levels, such as miR-E1k15, miR-Scr105, miR-Scr109 and miR-Scr113, did not develop microcephaly, whereas the lines with low levels of RFP expression, such as miR-E1k32 and miR-Scr103, developed microcephaly (Table 1).
For example, fitness recovery is undesirable with attenuated vaccines and with transgenic animals/plants that might escape into natural populations.
For example, Oact1 (O-acetyltransferase (membrane bound) domain containing 1) was 6.4-fold up-regulated in adenocarcinoma when compared with transgenic but healthy cells.
For example, transgenic plants with enhanced SOD activity exhibit increased tolerance to oxidative stress [ 22, 24, 25].
For example, transgenic mice with elevated HDL [ 9] or LDL concentrations [ 10] are protected against lethal endotoxemia and severe Gram-negative infections.
For example, transgenic mice with mildly elevated muscle PGC1-α are resistant to diabetes and have a prolonged life-span [ 35].
For example, transgenic mice with increased expression of IGF1 in the retina exhibit signs of diabetes-like eye conditions, including pericyte loss, retinal capillary BM thickening, venule dilatation, IRMAs and possibly retinal neovascularization (Ruberte et al., 2004).
For example, transgenic mice with the firefly luciferase gene under the control of the promoter of either iNOS (Zhang et al., 2003), NF-κB (Carlsen et al., 2002) or IL-1β (Li et al., 2008) have been developed.
Transplanted cells could also be modified to reduce susceptibility to malignancy; for example, transgenic mice with extra copies of the p53 [ 98] and INK4A [ 99] tumour suppressor genes have a substantially decreased incidence of malignancy in the absence of apparent adverse consequences.
