But he says the case is different for people known to be at high risk - for example families with genetic conditions that predispose them to sudden death.
For example, mice with genetic overexpression of 11 β-HSD1 have high blood pressure but mice with genetic knockout of 11 β-HSD1 are normotensive.
For example, associations with genetic disorders like Down's syndrome [ 4] and influences of atopic dermatitis and eye rubbing have been described [ 5].
Unlike FtH, FtL does not seem to have a major role in iron homeostasis since, for example, subjects with genetic hyperferritinemia-cataract syndrome have nearly 10-fold higher FtL than normal with no obvious abnormalities in iron metabolism [61,62].
As an example, an individual with genetic vulnerability to AN might become ill by exposure to high-risk environments like figure skating or fashion shows.
The current OSHA rules governing laboratories, for example, were not written with genetic manipulation of viruses and bacteria in mind.
For example, in the models with genetic alterations, although the proteins encoded by the genes of human and rodents are highly homologous, the regulation of gene transcription by transcription factors or epigenetics, or the regulation of gene translation by microRNAs, can vary extensively between humans and rodents.
For example, GWAS-identified associations with genetic variation in intergenic regions could be investigated with PheWAS to discover other potential associations.
A genetic basis for differences in resistance to Salmonella has also been shown with SLC11A1 (NRAMP1), the seminal example of a gene with genetic variants dramatically affecting resistance to bacterial infection [ 29, 30].
For example, studies in mice with genetic deletions of D-type cyclins have shown that the hematopoietic system is the only tissue that requires D-type cyclins for cell proliferation (Kozar et al., 2004).
