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Organs form relatively late, compared, for example, with early embryonic patterning decisions.
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For example, patients with early stage AD regularly exhibit declining mitochondrial energy metabolism and ATP production, which may subsequently cause synaptic loss and neuronal damage [ 19– 219.
For example, patients with early stage, lymph node-negative breast cancer have approximately 25% risk of dying from breast cancer within 10 years if they do not receive adjuvant treatment, whereas 75% however, will survive 10 years even without any further treatment (Chia et al, 2004).
However, there seems to be a fine line between "simple" and "too easy to make a mistake" — for example, with some early users complaining that they have inadvertently started chats with coworkers when they haven't intended to.
One example with the early animation being cartoonish was that the doors behaved liked rubber when slammed.
Third, it is questionable whether assessment of the risk of extubation failure should be performed beforehand without any post-extubation reassessment: For example, a patient with early signs of respiratory failure (e.g., desaturation within 1 h from extubation) but no pre-defined risk factors might be regarded as more at risk than a patient presenting only some pre-extubation risk factors.
For example, among those with early menarche (age <14), 60% were married and only 16% were not yet sexually active at age 17, compared to 11% married and 71% not yet sexually active among those with late menarche (age ≥16).
For example, in women with early stage BC who were treated with conservative surgery and radiation therapy (N = 1,624), there was a dose-dependent relationship between radiation and rib fracture incidence [ 23].
For example, a patient with early loss (MD = −4 dB) and a rapid rate of progression (−2 dB/year) can be expected to have total visual disability (−30 dB) in 13 years.
Many researchers believe the use of amyloid imaging and other biomarkers can help improve clinical trials by helping to exclude patients with other conditions, for example, and identifying patients with early stage disease.
Indeed, prevention of bone metabolism imbalance, through bisphosphonates therapy for example [18], in combination with early treatment of tumor progression and pain development – as well as their timely evolution – could be monitored using PET and MRI co-registration technology.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com