Critical illness can readily be conceptualized as a process of repetitive acute insults, starting, for example, with an acute life-threatening insult such as multiple trauma and haemorrhagic shock.
Patients who needed deeper sedation for medical reasons (for example, those with acute lung or brain injury) had a lower target score on the COMFORT-B (<11).
Diagnosing brainstem pathologies solely on clinical considerations is not always feasible, for example, patients with acute vascular events or encephalitis typically present with altered sensorium or in a comatose state which make brainstem localisation virtually impossible.
For example, rats with acute methamphetamine-induced behavioral sensitization have changes in mitochondrial dysfunction, oxidative, cytoskeletal, and synaptic proteins, which may hold clues to the nature of drug-induced psychosis [20], [21].
For example, associations with acute lung injury and nosocomial infections have been described, which could neutralize any physiological advantage [ 11- 13].
22 Second, the typical chronic nature of MNDs does not command a sense of urgency to act, for example compared with acute epidemics or famines.
H. influenzae is, for example, associated with acute otitis media in children, with sinusitis and pneumonia in adults as well as exacerbations in patients with chronic obstructive pulmonary disease (COPD).
For example, patients with acute coronary syndromes were at a higher risk of bleeding (2.2% for rivaroxaban in the ATLAS ACS 2-TIMI 51 trial) as they were typically treated with antiplatelet agents.
For example, patients with acute respiratory distress syndrome have been ventilated using a small tidal volume and an 'open lung approach' since publication of the study by Amato and coworkers [ 17].
For example, someone with acute angina may experience limitations in their daily activities which limits the amount of exercise they can comfortably perform, and which in turn increases their BMI.
