In the above study, for example, trial-to-trial variation gave 0.5 in correlation coefficients, which is much higher than the correlation coefficient value of stimulus selectivity of 2 cells (Kreiman et al. 2006).
However uncomfortable the idea may be, it must be the case that, in a democratic society, even those who deny rights to others have rights themselves - for example, to a fair trial.
Mainly due to slight differences in the inclusion criteria (for example, restriction to trials with a minimum of 6 weeks observation or with a minimum quality score) the respective study collections differed to a considerable amount.
For example, to conduct a clinical trial with sufficient statistical power to detect a 10% absolute decrease in the incidence of AQMS, a randomized clinical trial would have to enroll 800 patients in each of the two groups, assuming censoring due to mortality is 30%.
Cluster randomised trials also have different methodological issues and concerns when undertaking a pilot trial – for example to estimate the intra-class correlation (ICC).
Having a simple and accurate tool that could predict future risk of dementia would be beneficial not only to researchers (for example, to stratify samples for clinical trial recruitment) but, from a clinical perspective, might also help to provide stratified or personalised care.
His team would like to conduct field trials, for example, to gauge potential leakage and other possible environmental side effects.
We also aim to use the SCAN-B infrastructure to identify patients who may benefit from participation in specific clinical trials, for example to select patients whose gene expression or gene mutation status suggests sensitivity to an emergent therapeutic.
Indeed, biomarkers of disease are often an aid in clinical trials, For example, to stratify patients so that only those likely to respond to a particular therapy receive it.
This provides a strong rationale to investigate these safe and well-tolerated agents in clinical trials, for example to assess the impact of FADs in reducing myocardial injury in acute coronary syndromes or in patients undergoing predictable organ injury, e.g., surgery.
