There are additional system dependent uncertainties in flexible fitting, for example due to experimental noise in the cryo-EM maps, or as mentioned above, due to the inherent ambiguity of placing many thousands of atoms into a low-resolution dataset (Wriggers, 2004).
Finally, the "H-4" diagnostic part is used as an example to verify the experimental results.
If the users only wish, for example, to work with experimental data, they can filter the file first, remove all predicted data and then run MIscore.
Our model is then applied to three representative examples and compared to experimental data.
We chose to focus our work on QSAR based on structural molecular descriptors because QSAR based on KOW or SW, for example, are prone to experimental errors in the input variables, which can result in some statistical problems (Lohninger, 1994; Nguyen et al., 2005; Sabljic and Piver, 1992).
Consider one more experimental example to prove the point: the ultimatum game.
Analysis of gene-expression microarray data led us to focus on one particular gene, HAVCR1, to use as an example to further validate the experimental approach.
These data provide a very useful experimental example to increase understanding of the initiation and development of synovial inflammation systemically and dynamically, and also provide an interesting target for RA treatment.
To corroborate that these peak shifts are not just artefacts that are due for example to changes in the experimental setup geometry by a longer distance between the sample and the CCD camera detector, bulk XRD analysis with a standard powder X-ray diffractometer were performed (Supporting Information, Figure S3).
In a model of sepsis, for example, to what extent might the experimental animals conform to the established criteria for human sepsis?
