For example, the combinations of bortezomib and the histone deacetylase (HDAC) inhibitor vorinostat, 72– 74 bortezomib and the heat shock protein 90 (Hsp90) inhibitor tanespimycin, 75 and bortezomib and the Akt pathway inhibitor perifosine 76 have been evaluated in early phase clinical trials involving patients with relapsed and/or refractory MM.
Table 1 shows as an example the combinations of two consecutive amino acids (bi-codons), where the second amino acid is aspartic acid (both codons for aspartate begin with AG, therefore the occurrence of a stop codon in frame -1 depends entirely on the first codon).
One strategy has been to combine temozolomide with other agents; for example, the combination of extended schedule temozolomide and thalidomide (Hwu et al, 2005) can be administered safely and results in responses in just over 10% of patients.
For example, the combination of meperidine and buspirone has already been applied to facilitate induction of hypothermia in human trials.
For example, the combination of an imposed archway, spindly bushes and clumps of brush in "I Kept Separate" creates barriers that prevent the viewer from ranging into distant space, enforcing the isolation implicit in the picture's title.
At its best that could yet prove to be a healthy fusion – take, for example, the combination of voter-friendly retail offers on energy prices against a backdrop of structural energy market change.
For example, the combination of receptors activated when we smell a rose tells us that it smells nice, as opposed to the feedback we would get from the combination of receptors activated by rotting fish.
Some reactions are even faster than the hydrogen-oxygen explosion for example, the combination of atoms or molecular fragments (called free radicals) where all that occurs is the formation of a chemical bond.
For example, the combination of anti-cytotoxic T lymphocyte-associated antigen 4 (CTLand anti-programmedmmed cell death protein 1 (PD1) immune checkpoint inhibitors essentially doubles the response rate in certain patients with metastatic melanoma.
The design of structures subjected to environmental loads, e.g. offshore platforms, ships, aircrafts, tall buildings, would usually include analysis of combinations of load effects, for example, the combination of stress components in structural joints.
For example, the combination of product attributes that modeled for the emotions or Kansei word of attractive.
