Suggestions(1)
Exact(1)
The single example proof of concept at CTLA4 (now Figure 5A) demonstrates that a cluster of disease-associated polymorphisms are found in Treg lineage-specific enhancers, which acts as both an example and as proof of concept that if the polymorphisms in this cluster are functionally altering disease course, than they most likely do so through differential Treg cell function.
Similar(59)
Further studies with more frequent testing would be needed to validate this approach but this example provides proof-of-concept that memory performance can be tracked and the effects of treatment monitored using such continuous-report measures.
We use this example principally as proof-of-concept.
For example, in the proof-of-concept studies the inhibitors of Raf/MEK/ERK mitogenic kinase cascade and the IKK/NF-kB module reduce influenza virus titer in the lungs of infected mice after local aerosol administration into the trachea [reviewed in 14].
This report provides a wonderful example of a proof-of-concept study indicating that FMT may represent an ideal therapeutic alternative to control systemic inflammation in patients with sepsis.
As an example, for short proof-of-concept phase II clinical trials, the slow progression of JSN relative to the biological variation may require large study populations – here the biochemical markers may be an appealing alternative.
In this scenario, the IDS still performs the same function of identifying patterns of malicious behavior on a system that may be compromised [24]; for example a proof of concept based on the Snort IDS successfully prevented a Distributed Denial of Service (DDoS) attack [25].
In this study, the FITC-conjugated cyclic RGD peptides (e.g., FITC-Galacto-RGD2) are used only as examples to demonstrate proof-of-concept for the general approach to stain tumor tissues with small peptide-based fluorescent probes.
Proof-of concept experimental results are provided.
The debate has fixated on behavioural economics (rather than the wider evolving behavioural science landscape) and a handful of flagship examples as proof of concept: the towels in the hotel rooms, the organ donation opt outs, the perverse incentives for parents who pick their kids up late etc.
Identification of the prognostic significance of HER2 and its targeted therapy provides the best examples of proof of concept [ 22].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com