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For example, progression through the S-phase is required for the expression of even-skipped during specification of cell identity in the central nervous system of Drosophila [8].
For example, progression of LTBI to active disease can occur following TNF-α blocking treatments for chronic inflammatory diseases [5], while genetic defects involving IL-12 (as for IFN-γ [9]) increase susceptibility to development of active TB disease [6].
For example progression through G1 and into S phase is controlled by the CDK2 kinase activity and is stimulated by the sequential binding of cyclins D and E. Premature progression is prevented by the several CKIs such as p16, p27Kip1 and p21.
Unusual sleep stage transitions were noted (for example progression from stage 1 to REM sleep).
For example, progression of sarcopenia can be attenuated by physical activity, but depressive symptoms may decrease motivation to exercise [ 8, 9].
For example, progression may accelerate with increasing age so that the rate of progression is 2-fold faster at age 60 than it would be at age 30, given the same duration of disease and other characteristics.
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30 An outcome was consequently classified as a surrogate if it was a biomarker 12 (for example, low density lipoprotein cholesterol level) or an intermediate outcome (for example, progression-free survival) 13 31 judged to be a substitute for a final outcome.
Binomial exact estimator and its 95% CI was calculated for the evaluation of the main endpoint (RR according to International Working Group for Myelofibrosis Research and Treatment) and other categorical efficacy variables (for example, progression-free survival and progression-free survival at fixed time points).
And so it's not necessarily where you start, it's where you progress to, and she's a wonderful example of progression.
Although all of these phenotypic hallmarks are shared between RXRs and Notch mutant mice, they also exhibit certain differences; for example disease progression of the RXRs mutant mice appears to be milder, it affects primarily ear skin and later to a lesser extent dorsal skin.
No clinical end points, for example, cancer progression- or disease-free survival were evaluated in either study (Palm et al, 1998, Makimura et al, 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com