In addition to the examples previously described, Sect.
In order to show the effectiveness of our approach, we apply it to several examples previously described in the literature.
For example, a previously described SLP-76-Nck-WASp complex may control actin reorganization independent of Rho-protein involvement [6], [15], [16].
This study therefore provides a novel example where previously described intraspecific genotype/phenotype associations occur at the macroevolutionary level.
For example, we have previously described serotype G8 to be a locally prevalent serotype in Blantyre, Malawi (6 ).
6 For example, we have previously described the clinical presentation of individuals with acute mania and HIV infection.
For example, the insert previously described included no L1HS sequence, while the insert of the chr4 element into chr5 included 69bp of the 3' end of the (negative-strand) L1HS together with 931bp of unique chromosome 4 material downstream of this end.
In Kapit, Sarawak, for example, A. leucosphyrus (previously described as A. latens) was identified in 2006 as a P. knowlesi vector of both humans and monkeys and demonstrated relatively high human biting rates within a farming area at the forest fringe.
A fundamental difference between the ACEχ2 and other statistics is that ACEχ2 examines the codon usage variation for a large portion of the genome (the core of shared genes in these examples), whereas the previously described methods examine how the codon usage frequencies of a specified subset of genes differs from the genome-wide average [ 8, 10, 46].
For example, previously we described the trafficking routes of vesicles containing different autophagy proteins that ultimately fuse to give rise to autophagosome precursors and used this basic information to understand how these processes were disturbed by a mutation that causes Parkinson's disease and by a gene in a GWAS locus for Alzheimer's disease.
