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The functional ingredient in a functional food or in a nutraceutical/dietary supplement can be a macronutrient (for example, n-3 fatty acids), a micronutrient (for example, vitamins), or an ingredient with little or no nutritive value (for example, phytochemicals) [ 10].
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Examples include phytochemicals such as flavonoids and long-chain polyunsaturated fatty acids, that have anti-inflammatory actions, that may have important effects on muscle function.
Examples of certain phytochemicals with structures are shown in Fig. 5.
For example, thymoquinone, a phytochemical compound extracted from Nigella sativa, has anti-inflammatory, antioxidant, and anticancer effects.
For example, although curcumin, a phytochemical present in herbs and spices, possesses various biological activities and inhibits the growth of various cancer cells in vitro, its low systemic bioavailability following oral dosing has been suggested to limit access of sufficient concentrations for pharmacological effect in certain tissues [ 26].
For example, the histochemical techniques and phytochemical methods have been applied in the distribution and accumulation of active components in Sinomenium acutum, Aloe vera var.
For example, plants rich in different phytochemical derivatives such as triterpenes, flavonoids or polyphenols, have been reported to exhibit antihepatotoxic effects in experimental liver-injury models induced by different types of hepatotoxicants, such as carbon tetrachloride, cadmium, galactosamine, acetaminophen and thioacetamide [ 11, 12].
Examples include drugs as well as various phytochemicals, e.g. phenolic compounds.
Considerable evidence supports the hypothesis that flavonoids and other polyphenolic phytochemicals contained in certain foodstuffs, for example onions, red grapes, nuts and green tea, mediate, or contribute to, the putative cancer chemopreventive properties of their dietary sources.
The tested phytochemicals are just a few specific examples of amphiphiles that partition into the membrane and thereby become promiscuous modifiers of membrane protein function.
Examples are methyl-group donors, selenium, fatty acids, and phytochemicals, such as flavonoids, retinoids, isothiocyanates, and allyl compounds [ 2].
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