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The insulin-dependent delivery of GLUT4-containing vesicles to the plasma membrane is a specialised example of regulated membrane trafficking [17].
This result provided an interesting example of regulated inter-individual variability in gene expression that is associated with a physiological output in a metazoan.
Insulin-regulated GLUT4 translocation is an example of regulated membrane traffic, and like all such events utilizes the SNARE machinery to mediate both fusion of the GSVs with the plasma membrane and the sorting of GLUT4 into the GSV compartment.
The example of regulated variability in stem cells versus more differentiated cells 104 opens up the possibility that this is a more general mechanism, and that regulation of variability, along with the constraints of the landscape topography, could fine-tune stability and flexibility of defined T-cell types.
However, whether DUSP6/ MKP- 3 induction represents a negative-feedback control or an example of regulated cross-talk between two intracellular signalling pathways is controversial, as essential roles have been proposed for both ERK MAPK and PI3K signalling in regulating DUSP6/ MKP- 3 expression [ 10– 15, 15].
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This is the first example of regulating mitochondrial translational machinery by a PTK independent of its kinase activity.
For example, in the case of regulating carbon emissions, Cruz says that congressional authority must be granted to regulate those emissions.
Another example of differentially regulated genes, of interest in the context of M. tuberculosis infection, is the family of genes encoding the vesicular (v -ATPase subunits (Figure 3B), as the mycobacterial phagosome has been reported to av -ATPaseon with v-ATPasubunitsssing intracellular vesicles in Mφs [31], [32].
The inactive X chromosome (Xi) is a striking example of developmentally regulated heterochromatin formation in mammals.
An example of developmentally regulated antisense transcript levels is shown in Figure 3B.
In cluster 2, expression (for example, of Cold regulated gene and dehydrin family protein) was up- or downregulated in accordance with changes in day length.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com