As an example of locus-specific regulation it has been proposed that enhancer RNAs activate corresponding genes in cis via their product [ 25].
Additionally, the set of all known PC exons and UTRs from the Ensembl 62 database was used as an example of loci believed to be under both negative and positive selections (Halligan et al. 2013).
To conclude, though FTO locus provides a strong example of T2D locus with an effect on measures of fatness, in general the direct effects of T2D loci on measures of fatness are limited.
Small data providers, for example, curators of Locus Specific Databases for a small number of genes, have fewer opportunities to exert access control and simply rely on database copyright protection [ 31].
Here, we discuss two examples of loci, the transcripts of which exhibit simply distinguished striking opposite regulation in Nipponbare.
Unlike the cases of histone methyltransferases or histone deacetylases where multiple examples of loci under direct control of the corresponding HMTs or HDACs exist, there is no good target gene-based system for histone demethylase studies.
Examples of loci with protein factors are known but not provided.
Intriguingly, we also identified several examples of loci where multiple NCO tracts cluster within 20 30 kb intervals, as well as instances of complex CO over extended intervals.
However, there is an accrual of emerging examples of loci discovered in founder populations that are more widely generalizable, with replication of signals achieved in diverse sample sets [ 4, 5, 7- 9].
51.6% QTL showed antagonism across at least one environment (p-value < 0.05, Figure S2 and Figure S3). Figure 2, A−C shows examples of loci exhibiting AP across various environments.
