Another example of gain-of-function in p300/CBP is in viral transformation.
TRIMCyp is a very interesting example of gain-of-function by retro-transposition in the TRIM5 gene in several monkey species.
Typically, the gain functions are chosen sigmoidal, for example, (up to affine transformations of the argument) f ( u ) = ( 1 + e − u ) − 1 or f ( u ) = ( tanh ( u ) + 1 ) / 2. These examples of gain functions are bounded, infinitely often differentiable with bounded derivatives.
Figure 2 shows examples of gain only, loss only and complex CNVRs.
Characteristics of the 161 Examples of Genomic Loss and 88 Examples of Gain Observed upon RECQL5 Knockdown, Related to Figure 5 Table S3.
Genes and Transcripts in the 161 Examples of Genomic Loss and 88 Examples of Gain Observed upon RECQL5 Knockdown, Related to Figure 5 Document S1.
The Wiener filter is one example of a gain function, and any other gain function can be employed using the obtained speech and noise PSD estimates.
Recent examples of gains in managing the need for stress-tolerant rices are uncovering (i) genes for submergence tolerance for rice grown in monsoonal regions (Xu et al. 2006), and (ii) genes for drought tolerance for varieties grown in conditions of water scarcity or drought (Kumar et al. 2014).
We surmised that the recurring genomic rearrangements (22 examples of loss, 10 examples of gains; Figures 5A, right; see also Figures 5C and 5D) could be key to understanding RECQL5 function, so we initially focused on these high-confidence events.
This displacement was achieved with a nitrile group, presenting an example of efficient gain in binding affinity with minimal increase in molecular weight.
