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The EMA approval of Inflectra is an example of extrapolation of indications.
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Conversely, with regard to the approach pursued here, there seem to be no examples of extrapolation of the field received at the points of a straight segment (and due to remotely distributed sources) beyond the limits of the segment itself.
Fig. 3 Example of field extrapolation.
As mentioned above, NOAELs usually are divided by assessment factors considering, for example, the uncertainty of extrapolation of data gained with certain test organisms in the lab to toxicity thresholds applicable for human health protection (factor = 10) and the between humans differences in sensitivity (factor = 10).
"This paper is a typical example of the speculative extrapolation that... archaeologists and anthropologists often do," Finlayson says.
THOMAS Malthus hasn't had a very good press over the last couple of centuries, often being cited as a classic example of the dangers of extrapolation.
We show on Fig. 3 two examples of such extrapolations, made by Langlais and Mandea (2000).
An example of this may exist with extrapolation of use of eculizumab to Stx-HUS.
In some cases, mathematical methods of extrapolation may be used, for example using data on historical trends, which could help in the estimation of distributional properties.
For example, simple linear extrapolation of the relationship between IQ and STX1A in WS predicts normal IQ from normal STX1A expression (Fig. 4).
His tremendous powers of distillation require, in return, a bit of extrapolation.
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