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The model is an example of endogenous growth approach in which one can study different types of technological progress.
Although most studies have been oriented toward neuronal regeneration, myelin regeneration is the most obvious example of endogenous spontaneous brain repair.
Deacon [ 27] gives the example of endogenous ascorbic acid synthesis (vitamin C) existent among some primate lineages and missing in others.
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Examples of endogenous clathrin and SNX9 at the tip of comets are now shown in Figure 5E.
Hence, they are of interest as examples of endogenous DNA damage that may initiate cancer [ 41, 44].
Examples of endogenous mutagenic processes are DNA replication (i.e. polymerase fidelity and replication slippage), post-replicative DNA mismatch repair and methylation-mediated deamination of cytosines in CpG dinucleotides [ 5- 9].
For example, knockdown of endogenous dysbindin with siRNA has been shown to reduce glutamate levels in cultured neurons, suggesting that a decrease in dysbindin levels has synaptic consequences [7], [10].
This example of an endogenous "beta-arrestin-biased" 7TMR that signals through beta-arrestin in the absence of G protein activation demonstrates that some 7TMRs encoded in the genome have evolved to signal through beta-arrestin exclusively and suggests that other receptors that are currently thought to be orphans or decoys may also signal through such nonclassical pathways.
ChM1 is the first example of an endogenous molecule that possesses two different anti-tumor actions.
CpoB is the first example of an endogenous regulator that can control the TPase activity of a bifunctional PG synthase independently of its GTase activity.
Thus, our data represent the first example of an endogenous metabolic abnormality, namely DM, which is associated with a functional inhibition of the Hh signaling pathway.
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