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An example of dose distributions for prostate tumors with VMAT and conventional IMRT is displayed in Figure 4.
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Finally, CT radiation dose from hybrid imaging systems was addressed by giving some examples of dose assessment in the limited context of anatomical localization and attenuation correction.
Figure 1 shows typical examples of dose distribution image and DVH analysis in one patient who underwent RT.
Examples of dose-sensitive genes include Flt3, whose expression is reduced in Sfpi1 +/− progenitors (49), and Sfpi1 Blac/Blac and Sfpi1 BN/BN mice that show a dose-dependent suppression of various T-cell and natural killer cell genes in interleukin-3 dependent myeloid cell lines (42).
Examples of dose-response curves for three cell lines with different levels of 5FU sensitivity are given in Figure 2. The cell lines were divided into three sensitivity groups, ranging from sensitive (HDC73 to VACO10MS, 0.03 1.70 μ) to intermediate (HDC54 to SKCO1, 1.76 6.14 μ) to resistant (SNUC2B to HCT15, 6.18 47.5 μ), as shown in Figure 1.
An example of nonlinear dose dependence adds to the complexity.
An example of standard dose distributions for head and neck cancer is displayed in Figure 3.
An example of a dose distribution in a very large tumor is shown in Figure 1.
A good example of a dose defining insulin infusion protocol was recently published by Braithwaite et al. who reported the results in 24 trauma patients [ 31].
Although in hospital practice there is familiarity with using the Cockcroft-Gault method of calculation of CrCl, for example, for dosing of aminoglycosides, this is not the case for drugs that are used in primary care.
An example of a dose-response profile of gene A2m for compound sulindac is shown in Fig. 1.
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