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This example of an endogenous "beta-arrestin-biased" 7TMR that signals through beta-arrestin in the absence of G protein activation demonstrates that some 7TMRs encoded in the genome have evolved to signal through beta-arrestin exclusively and suggests that other receptors that are currently thought to be orphans or decoys may also signal through such nonclassical pathways.
ChM1 is the first example of an endogenous molecule that possesses two different anti-tumor actions.
Thus, our data represent the first example of an endogenous metabolic abnormality, namely DM, which is associated with a functional inhibition of the Hh signaling pathway.
In contrast, [F]FET is an example of an endogenous F-labelled compound where the introduction of the radionuclide is performed by an F-fluoroalkylation reaction.
CpoB is the first example of an endogenous regulator that can control the TPase activity of a bifunctional PG synthase independently of its GTase activity.
Xanthurenic acid is an example of an endogenous ER stressor provoking an accumulation of unfolded proteins which in turn leads to an overexpression of Grp 94 and calreticulin in the lens epithelial cells of young mammals [ 15].
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For example, the specificity of an endogenous hydrolase might be altered by binding one of our helical bundles.
These examples take advantage of an endogenous ligand and a known enzyme inhibitor.
Here, we demonstrate the feasibility of TREC-IN in the Mmc genome using two examples a) replacement of an endogenous gene with an orthologous one, and b) essential gene complementation in a genome reduction study.
In contrast, we are not aware of an example where an inactivation of an endogenous heterochromatin-euchromatin boundary element produces a toxic spread of heterochromatin.
It has been suggested that the syphilis epidemic in the United States is a 'rare example of unforced, endogenous oscillations in disease incidence, with an 8 11-year period that is predicted by the natural dynamics of syphilis infection, to which there is partially protective immunity' (1).
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