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There is at least one other known example of a transgenic mouse line where transgenes have integrated as inverted repeats and are expressed at an unexpectedly low efficiency [ 26].
To our knowledge, this is the first example of a transgenic mouse expressing an artificial gene coding for a zinc finger based transcription factor.
To our knowledge, this is the first example of a transgenic mouse expressing an artificial zinc finger transcription factor working on its endogenous target gene.
Bt cotton is an example of a transgenic plant variety.
Another example of a transgenic mouse model is the TβRIIΔk-fib model.
Over expression of the mouse Ren-2 gene in various rat tissues was the first example of a transgenic model of hypertension [ 71].
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An example of such a transgenic model is the TβRICA; Cre-ER transgenic mouse expressing constitutively active TβRI in fibroblasts.
For example, generation of a transgenic hamster overexpressing proprotein convertase subtilisin/kexin type 9 (PCSK9), a protein involved in cholesterol homeostasis by inducing LDL receptor degradation, will be highly desirable.
This would create problems when testing in an animal model situation unless appropriate measures are made, for example, the generation of a transgenic rat model.
For example, in a transgenic mouse model of AD where no irradiation took place, it was observed that when TGFβ production was blocked, CD11c+ macrophages migrated to the CNS and mitigated AD-like pathology (Town et al., 2008).
This is the first example of a successful introduction of transgenic animals into control of biologicals.
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