This represents the first example of a stable and potent (Ki = 340 nM) reversible inhibitor of firefly luciferase activity based on the structure of the natural acyl-adenylate intermediate.
MGP for example is a potent inhibitor of calcification both in bone and in the vasculature [ 8].
The antifungal drug posaconazole for example, is a potent inhibitor of the T. cruzi sterol 14α-demethylase (CYP51) and has shown significant antiparasitic activity in vitro and in vivo (16 – 16).
For example, leflunomide, a potent nontoxic inhibitor of the rate-limiting enzyme of the de novo synthesis of pyrimidines, dihydro-orotate dehydrogenase [ 85], selectively decreases the activation of proinflammatory Th1 cells while promoting Th2 cell differentiation from naïve precursors [ 86].
"The myth has proved so enduring that you will still read, in many apparently authoritative sources, that the original idea for converting the palace into a hospital came from the king". As an example of the potent myth-making, Beevers points to the beautifully produced souvenir book, a copy of which is included in the exhibition.
As an example of the potent myth-making, Beevers points to the beautifully produced souvenir book, a copy of which is included in the exhibition.
Wiretaps, for example, remain a potent investigative technique despite public awareness of their general existence.
The memo, which ran to sixteen pages, started off with a bow to Steven Sinofsky's epiphany at Cornell: "The Internet is an example of a rare and very potent phenomenon — the birth of a new platform".
A predominant example is FGF2, a potent stimulator of muscle fiber proliferation and a strong inhibitor of differentiation [ 35, 37].
For example, ATO is a potent inducer of histone hyperacetylation (Perkins et al, 2000; Chen et al, 2001).
